46Health and safety informationthe studies demonstrated the existence of any harmfulhealth effects from wireless phones RF exposures.However, none of the studies can answer questionsabout long-term exposures, since the average periodof phone use in these studies was around three years.What research is needed to decide whether RFexposure from wireless phones poses a healthrisk?A combination of laboratory studies andepidemiological studies of people actually usingwireless phones would provide some of the data thatare needed. Lifetime animal exposure studies could becompleted in a few years. However, very largenumbers of animals would be needed to providereliable proof of a cancer promoting effect if oneexists. Epidemiological studies can provide data that isdirectly applicable to human populations, but ten ormore years' follow-up may be needed to provideanswers about some health effects, such as cancer.This is because the interval between the time ofexposure to a cancer-causing agent and the timetumors develop - if they do - may be many, manyyears. The interpretation of epidemiological studies ishampered by difficulties in measuring actual RFexposure during day-to-day use of wireless phones.Many factors affect this measurement, such as theangle at which the phone is held, or which model ofphone is used.What is FDA doing to find out more about thepossible health effects of wireless phone RF?FDA is working with the U.S. National ToxicologyProgram and with groups of investigators around theworld to ensure that high priority animal studies areconducted to address important questions about theeffects of exposure to radio frequency energy (RF).FDA has been a leading participant in the World HealthOrganization international Electromagnetic Fields(EMF) Project since its inception in 1996. An influentialresult of this work has been the development of adetailed agenda of research needs that has driven theestablishment of new research programs around the