Entrance-aperture carrierDisc aperture assemblySample cone3.8.2 Replacing the entrance-aperture seal and discReplace the entrance seal aperture when these conditions apply:• You have dismissed LC and sample-related causes for decreased signal intensity.• Cleaning the source components fails to increase signal stability.Required materials• New entrance-aperture seal and entrance-aperture disc• Chemical-resistant, powder-free glovesWarning: To avoid personal contamination with biohazardous or toxic compounds, wear clean,chemical-resistant, powder-free gloves when performing this procedure.To replace the entrance-aperture seal:1. Dispose of the old entrance-aperture seal and disc according to your local environmentalregulations.2. Insert the new entrance-aperture seal and disc into the sample cone.Requirement: The Standard and Performance QDa Detectors require different entranceaperture discs. When ordering a replacement entrance-aperture disc and seal, ensure thatthe entrance-aperture disc is the correct type.3. Refit the source components (see Refitting the source components).3.8.3 Removing the ion blockClean the ion block when cleaning the sample cone assembly fails to increase signal sensitivity.Required materials• Chemical-resistant, powder-free gloves• 2.5-mm hex wrenchJune 15, 2017, 715003956 Rev. FPage 34