Service and Maintenance InformationSystem User Guide 4500 Series of InstrumentsRUO-IDV-05-0264-A 121 of 138Clean the Front-EndClean the mass spectrometer front-end using the routine cleaning method, to:• Minimize unscheduled system downtime.• Maintain optimum sensitivity.• Avoid more extensive cleaning that requires a service visit.Symptoms of contamination: Significant loss in sensitivity and increased background noise.When contamination occurs, perform an initial routine cleaning. Clean up to and including thefront of the orifice plate. If routine cleaning does not resolve issues with sensitivity, a full cleaningmay be necessary.This section provides instructions for performing routine cleaning without breaking vacuum andfull cleaning under atmospheric pressure, after venting the mass spectrometer.Note: Follow all applicable local regulations. For health and safety guidelines, refer toChemical Precautions on page 11.Note: U.S. customers can call 877-740-2129 for ordering information and inquiries.International customers can visit www.absciex.com.Required Materials• Powder free gloves (nitrile recommended)• Safety glasses• Laboratory coat• Fresh, high quality water (at least 18 Mohm de-ionized water (DI) or ultra-pure HPLC-gradewater). Old water can contain contaminants which can further contaminate the massspectrometer.• HPLC- or MS-grade methanol, isopropanol (2-propanol), or acetonitrile• Cleaning solution. Use one of:• 100% methanol• 100% isopropanol• 50:50 acetonitrile:water solution (freshly prepared)• 50:50 acetonitrile:water with 0.1% acetic acid solution (freshly prepared)Table 13-2 Tools and Supplies Available from AB SCIEXDescription PNSmall polyester swab (thermally bonded). Available in the Cleaning kit. 1017396Small lint-free wipe (11 cm x 21 cm). Available in the Cleaning kit. 018027
