Hanson Media-Mate Plus Operation Manual
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Contents
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Media-Mate Plus Operation Manual 25-710-800-OVolume Delivery CalibrationCalibration of volume delivery is recommended for all volume settings that will be used.Recalibration is recommended every six months for each setting used. Recalibration is alsorequired whenever the delivery volume has been fine adjusted (see Section 6 – FineAdjustment of Delivery Volume). To facilitate volume calibration, Hanson Researchrecommends the Volume Calibration Kit (p/n 25-710-705).1. Set Volume to desired increment (see Section 7 – Volume Selection).2. Hanson Research recommends performing volume calibration at room temperature. Settemperature control to the desired temperature and allow the media temperature tostabilize (see Section 7 – Temperature Setting).3. Place the Dispense Head over pre-numbered, plastic vessels (ref. p/n 25-710-705).4. Start the Media-Mate Plus cycle (see Section 7 – Operating Instructions).5. Using a calibrated laboratory scale, tare with empty vessel, weigh filled vessels, andrecord the actual media weight of the delivered volume for each vessel.6. Empty and dry the vessels and repeat Steps 1 through 5 for a total of 5 cycles.7. Calculate and record the media volume for each vessel. The density of the media at thecalibration temperature is required for the calculation below.Media Volume = media weight divided by media density at calibration temperature.8. Repeat all of the above steps for each incremental volume setting that will be used.Fine Adjustment of the Delivery Volume (one incremental setting only)When dissolution rate calculations are corrected for actual mean delivery volumes recorded, itshould not be necessary to fine-adjust the delivery volume. For applications that do require amore accurate delivery volume, adjust as follows:1. Calibrate volume at desired incremental setting (see Section 6 – Volume DeliveryCalibration).2. Review Calibration Data and identify adjusters that require finer adjustment.3. Fine adjustment is accomplished by accurately adjusting the Pointer position on the FillTube (see Figures 6-1 and 6-2). The Pointer must be moved approximately 0.0048 in.per mL of volume delivery change.EXAMPLE: To change delivery volume by 2.5 mL [ 2.5 X 0.0048 = 0.012 ], the Pointermust be moved 0.012 in.Section 6 Validation and Calibration 17 |
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