Hanson Media-Mate Plus Operation Manual
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Contents
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Media-Mate Plus Operation Manual 25-710-800-ODeaeration ValidationDeaeration is validated by running a standard instrument cycle and then measuring thedissolved oxygen content in each filled dissolution vessel. Dissolved Oxygen Meters are readilyavailable from laboratory suppliers such as Cole Parmer, (800) 323-4340.To avoid dissolution problems, the maximum dissolved oxygen content should not exceed 95%saturation at operating temperature (Handbook of Dissolution Testing, William Hanson, 3 rd ed.).The USP Dissolution Toolkit recommends a dissolved oxygen level of not more than 6 ppm.The Media-Mate Plus will meet this at 37 °C with 500 mL and higher volumes and/ortemperatures.Deaeration Validation must be performed with all user-input adjustments set and recorded onthe Deaeration Validation Log. Validation is recommended for each set of user adjustmentsthat will be used. Validation is recommended prior to the first use of the instrument and shouldbe repeated every six months.1. Set all user-input adjustments (see Section 7).2. Initiate an instrument cycle (see Section 7 – “Test Cycle”).3. Using a Calibrated Dissolved Oxygen Meter, measure the dissolved oxygen content ineach dissolution vessel.4. Record all user-input adjustment settings and dissolved oxygen readings on theDeaeration Validation Log.Temperature Controller (PID) Set-UpThe Temperature Controller (see Figure 6-3) has been programmed at the factory to obtainoptimum temperature control and quick heat-up time. The program set points are locked andshould not require changing or resetting. If the factory program has been altered for anyreason, it may be restored in accordance with Hanson Research Corporation ProcedureNumber 25-710-807, “Programming Procedures for Temperature Controller.” This procedureis available on request from Hanson Research Corporation (see Section 12).Figure 6-3: Temperature ControllerSection 6 Validation and Calibration 20 |
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